Nalbuphine hydrochloride is a synthetic opioid agonistantagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid analgesic, oxymorphone. Chemically nalbuphine hydrochloride is 17-(cyclobutylmethyl)-4,5α- epoxymorphinan-3,6α,14-triol hydrochloride. Nalbuphine hydrochloride molecular weight is 393.91 and is soluble in H2O (35.5 mg/mL at 25°C) and ethanol (0.8%); insoluble in CHCl3 and ether. Nalbuphine hydrochloride has pKa values of 8.71 and 9.96. The molecular formula is C21H27NO4• HCl. The structural formula is:


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What is Nubain, and how is it used?

Nubain is a prescription medicine used to treat the symptoms of Pain and as an Anesthesia Supplement. Nubain may be used alone or with other medications.

Nubain belongs to a class of drugs called Opioid Analgesics.

It is not known if Nubain is safe and effective in children younger than 1 year of age.

Nubain may cause serious side effects, including:

  • slow breathing with long pauses,
  • blue-colored lips,
  • difficult to wake up,
  • shallow breathing,
  • breathing that stops during sleep,
  • lightheadedness,
  • severe drowsiness,
  • severe constipation,
  • nausea,
  • vomiting,
  • loss of appetite,
  • dizziness,
  • worsening tiredness, and
  • weakness

Get medical help right away if you have any of the symptoms listed above.

The most common side effects of Nubain include:

  • drowsiness,
  • dizziness,
  • spinning sensation,
  • dry mouth,
  • headache,
  • sweating,
  • cold, clammy skin,
  • nausea, and
  • vomiting

(nalbuphine hydrochloride) ABBOTTS LABS 20mg/10ml x5 $212


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